Exploration and Innovation in Organ Biofabrication

【Abstract】

1. Since 2005, the team from the Biomanufacturing Center of Tsinghua University has established a theoretical and technical framework system for organism manufacturing engineering based on the controlled assembly of cells. They have proposed technical routes for constructing tissues and organs through direct and indirect controlled assembly of cells.

2. We have carried out in - depth research in three aspects: bio - inks and processing equipment for 3D cell printing, additive manufacturing technologies for biomimetic multi - scale tissue engineering scaffolds, and strategies and methods for constructing complex organs inspired by developmental processes.

3. We have expanded the application of biomanufacturing technologies in the construction of micro - physiological and pathological models of tissues, organs, and tumors.

【Bio】

Dr Xiong Zhuo is a full professor in Department of Mechanical Engineering in Tsinghua University, China. He is also the vice president of the Beijing Mechanical Engineering Society, the deputy director of the Beijing Key Laboratory of Biomanufacturing and Rapid Prototyping, and a standing member of the Biomanufacturing Engineering Branch of the Chinese Mechanical Engineering Society. In 1994, he entered the Department of Mechanical Engineering at Tsinghua University, where he obtained his bachelor's, master's, and doctor's degrees. Since 1999, he has been engaged in 3D printing research of tissue engineering scaffolds and invented the low - temperature deposition manufacturing process for biomaterials. He is one of the earliest researchers in the world to carry out cell 3D printing. He took the lead in proposing the cell 3D printing technology based on unit - controlled stacking and forming, and obtained the first invention patent. In 2004, he presided over the first funded project in the field of cell 3D printing by the National Natural Science Foundation of China. In 2005, he published a paper proposing "organism manufacturing engineering" and systematically expounded its principles and methods. He has conducted in - depth research in aspects such as tissue engineering scaffold manufacturing, cell 3D printing, and biomimetic construction of tissues and organs. The low - temperature deposition manufacturing process he invented has been widely applied to the formation of tissue engineering scaffolds. He has also developed a variety of 3D cell - printing techniques, and multiple devices have achieved commercial production. In 2023, based on the microsatellite platform, he pioneered the 3D printing of complex tumor models in space. He has won one Beijing Science and Technology Award and one Machinery Industry Science and Technology Award.