Wang Mian
Professor
Tongji University
Engineering human in vitro models toward functional and cell-dense tissue architectures
【Abstract】
1. Introduces a cell-dense bioprinting strategy (CLINK) by chemically modifying cell membranes with acrylate bonds, enabling living cells at physiological densities to function directly as bioinks.
2. Demonstrates the first photoactivated, layer-by-layer DLP bioprinting using purely cellular bioinks, overcoming the low cell-density limitation of conventional hydrogel-based bioprinting.
3. Enables rapid fabrication of tissue constructs with ultrahigh cell densities (~10⁹ cells mL⁻¹) that closely recapitulate native tissue architecture and function, including functional neural circuits and rhythmically contracting stem cell–derived mini-hearts.
4. Generates living implants capable of autonomous sensing, adaptation, and integration in vivo, promoting tissue repair and regeneration and establishing a broadly applicable platform for advanced tissue biofabrication.
【Bio】
Mian Wang is a Professor at the School of Life Sciences and Technology, Tongji University. His research focuses on the development of functional biomimetic tissues, organ-on-a-chip platforms, and in vitro models of maternal-fetal interactions. He was selected for the Shanghai Overseas High-Level Talent Program and the Pujiang Talent Program in 2022. Dr. Wang has led multiple competitive research projects, including a key subproject of the National Key Research and Development Program of China, as well as National Natural Science Foundation of China (NSFC) Programs. He has published over 40 SCI-indexed papers, including first or corresponding author publications in Cell, Nature Communications (2), Science Advances, Advanced Materials (2), and Advanced Functional Materials.
TCT Asia
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