The innovative application of three-dimensional printed custom-made prosthesis for bone tumor
【Abstract】
1. Application of 3D printing technology in prosthesis design and manufacturing
2. Personalized 3D printed prostheses are applied to repair bone defects after bone tumor resection
3. The porous structure promotes bone integration at the interface
4. The porous structure improves long-term stability of the prosthesis【Bio】
Zheng Guo, professor, chief physician, and doctoral supervisor, serves as the director of orthopedics department at Tangdu Hospital of Air Force Medical University, head of the orthopedic oncology Institute of PLA, and principal investigator (PI) of translational medicine research platform in science and technology innovation institute of Tangdu Hospital. Currently, he acts as vice chairman of Bone Tumor and Bone Metastases Professional Committee of the Chinese Anti-Cancer Association, leader of Digital Orthopedics Group at Medical Engineering Branch of the Chinese Medical Association, leader of Pelvic Science Group at Sarcoma Professional Committee of the Chinese Anti-Cancer Association, and a device reviewer of the National Medical Products Administration. He is also an expert in key research fields of intelligent robots at the Ministry of Science and Technology, and a core expert member of additive manufacturing and laser manufacturing at the Ministry of Science and Technology. He has served as the chief scientist twice for National Key research and development Program projects, and is a Chair Professor at Bone Tumor Research Center of Massachusetts General Hospital, Harvard University. He has undertaken 16 national, provincial, and ministerial-level projects and won the First Prize of National Science and Technology Progress Award, the First Prize of Military Medical Achievement Award, and the First Prize of the Shaanxi Provincial Science and Technology Award. He has been authorized 15 national invention patents and obtained 4 national III-Class medical device registration certificates. Notably, the world's first bio-coating cage and matching artificial vertebrae he developed were selected into 2023 "Science and Technology China" series list, becoming the only project of leading technology list in biomedical field from Shaanxi Province. He has published 221 academic papers, including 82 SCI papers as corresponding author in international journals such as "Biomaterials," "Bioactive Materials," and "Chemical Engineering Journal." He has chief-edited and co-edited 9 monographs, and led to writing 11 expert consensus, guidelines, and standards in the fields of bone tumors and medically additive manufacturing. Professor Guo has supervised 63 doctoral and master postgraduates and 7 postdoctoral fellows, and been awarded as an outstanding postgraduate tutor at Air Force Medical University.
He has long engaged in precisely surgical treatment of bone tumors assisted by digital intelligence technology and the research and development of innovative orthopedic products. In 2014, he led the completion of the world's first 3D-printed titanium alloy personalized clavicle and scapula prosthesis implantation surgery, pioneering the clinical application of 3D-printed personalized prostheses in China. He has been awarded 1 second-class merit citation and 4 third-class merit citations. He was honored with the title of "The Most Beautiful Doctor in Sanqin" by the Shaanxi Provincial Health Commission, and was awarded the title of "Sanqin Scholar" in Shaanxi Province for national first-class team leader, enjoying the first-class position allowance for outstanding professional and technical personnel in the military, and special government allowances from the State Council. He won the title of the 6th National "Bethune-style Good Doctor", and has been employed as a consultation expert by the Health Care Committee of the Central Military Commission.